Thứ Tư, 26 tháng 1, 2011

Find painful

Indications for surgical treatment should be placed with care, since some patients may eventually get better.

Chronic pancreatitis post-resection.

Theoretically, it is well known for regularly attacking postgastrectomy disorders of the nervous and humoral regulation of the pancreas.

Among the main causes of chronic pancreatitis include the following: first-operational trauma, leading to the development of acute pancreatitis, and then changes into a chronic, disorders resulting in the evacuation of the loop, which may as noted above, by itself have the character of clinically significant suffering, breach of the regulation of secretory gland function, coming off as a result of passage of the masses in the gut, which in turn leads to a sharp decrease in production of secretin.

Diagnosis. The clinical picture of post-resection pancreatic consists of a series of signs leading from which is a pain. Rather typical constant intensity and the intensity irradiation of pain. Often, patients suffer periodic diarrhea, lose weight.

Diagnosis of post-resection pancreatitis complicated by the limited capacity of physical and laboratory studies. On examination marked "transverse" tenderness to palpation in the projection of the pancreas, positive symptom Mayo Robson, gipnresteziya skin in the left hypochondrium. Important diagnostic value is computed tomography and ultrasound of the pancreas. Of the laboratory methods of research should be noted hypoglycemic curve with a double load, and determination of pancreatic enzymes by probing.

Treatment. Conservative treatment, diet, substitution therapy, procaine blockade of the splanchnic nerve, sedatives and painkillers. Surgical treatment is ineffective.
Recurrent peptic ulcers razvivayuisya usually in jejunum at the site of anastomosis with the stomach or near the anastomosis or in the duodenum.

The etiology and pathogenesis. Among the causes of peptic ulcer after brand viagra gastric resection should be called a lack of volume resection of the left portion of duodenum atruma, excessively long afferent loop, incomplete vagotomy, if it was done in conjunction with water-saving resection.

Occupy a special place peptic ulcer of endocrine nature (with parathyroid adenomas, Zollinger-Ellison syndrome), also in time may occur after gastric surgery, without, however, with a pathogenetic link.

Recurrence of ulcers may occur in different periods after surgery.

Diagnosis. The clinical picture of peptic ulcer is similar to the clinical picture of the former prior peptic ulcer disease. Course of the disease and the complaints of the patient more resistant, different persistence, remission periods are short. The pain is localized in the upper abdomen, often on the left, radiating to the back; relieved after eating or under the influence of antacids are short, frequently develop nocturnal pain.

Palpation in the epigastric area, usually on the left, you may find painful. Produce a study of gastric secretion, which revealed a high acidogenic function of the stomach.

X-ray examination and endoscopy are reasonably accurate methods of diagnosis of recurrent peptic ulcers.

Treatment peticheskoy ulcers without severe clinical symptoms should begin with conservative measures. If there is an expression of suffering that is resistant to antiulcer therapy, and development of complications of surgery is shown. The choice of method of operation depends on the nature of the disease and the causes that led to the development of peptic ulcers.

Postvagotomicheskie disorder. Disorders resulting from vagotomy, it is difficult to distinguish from the postoperative pathology.

Effect of vagotomy on gastric motor function in his neadakvatnom drainage can lead to phenomena gastrostaza that causes the complaints of patients as a feeling of heaviness, discomfort, fullness in the epigastrium.

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Thứ Năm, 20 tháng 1, 2011

Screen passes

Spanish doctors say that successfully conducted an operation on a full face transplant. Their patient is currently recovering.

As reported by the Air Force, all in the world was made about a dozen transplants face, but this seems to be the most complete.

Over the face of a man who was disfigured as a result of the accidental brand viagra online discharge within 22 hours of labor to 30 doctors from the hospital at the University of Val-d'Ebrona in Barcelona. The operation took place in March. Led the team Pere Joan Barrett. Patient transplanted all the skin and muscles of the face. He has a new nose, lips, cheekbones and teeth. All of this donor organs. The official representative of the hospital Bianca Bonte said that the patient feels well, he saw himself in the mirror and was satisfied with the result.

Injured patients received five years ago. Since then, he could not breathe independently, swallow and speak.

The first partial face transplant was done in 2005 in France. A woman who attempted suicide and was heavily bitten dog, while she was unconscious, transplanted nose, chin and lips. China has made a new man's face, which greatly crippled Bear. In the U.S., most of the face transplant woman, in which the husband is shot at point blank range.
March 15, 2010 in the building of the Russian Academy of Public Administration held the Third International Conference "Russian School of Colorectal Surgery. The participants were more than 450 surgeons from Russia, CIS, Poland, Serbia, China, Germany.

Conference participants were able to observe two operations sided hemicolectomy with the broadcast in real time.

Operations were performed by Professor Werner Hoenbergerom and head of Department of Coloproctology and Pelvic Floor Surgery, Professor Petr Tsarkova.

Professor from Germany demonstrated the technique developed by him full mezokolonektomii with cancer of the right half of the colon. A distinctive feature of the operation, which cialis without prescription demonstrated Werner Hoenberger is a nice selection of gut anatomical layers that are formed in humans before birth.

Petr Tsar'kov demonstrated technology selection of the colon and extended lymphadenectomy brand name levitra on the standards of Japanese cancer surgery.

In addition, the large screen passes Broadcast video presentations of scientific papers that have passed the final contest of scientific works.

The second part of the conference was devoted to lectures by leading Russian and foreign experts on the topic of surgical treatment of colon cancer. This was followed by presentations.

At the end of the day summed up the scientific research competition.

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Chủ Nhật, 9 tháng 1, 2011

Symptomatology

Pathognomonic symptoms of HF are pain, bulging knots and bleeding, which usually develops after or during defecation, and rarely leads to significant blood loss and anemia. Considered a significant cause of rectal bleeding NG should only be when other diseases, most often leading to this state. In most cases, hemorrhoidal bleeding is noticed on the trail of blood on toilet paper.

Exacerbation of HF is always more or less painful. Ulceration, or thrombosis of the nodes can cause severe pain, in some cases, disabling the patient. Very strong pain syndrome develops when a particular form of the disease an acute attack of hemorrhoids, which refers to impairment of sharply swollen or thrombosed hemorrhoids. Thrombosis NG can lead to bulging of the perianal region and the typical foreign body sensation in the anorectal region and, in some cases, complicated by gangrene of hemorrhoids.

SH decompensation in most cases is less painful than NG. SH characteristic for a sense of incomplete defecation or her inability, a feeling of fullness in the rectum syndrome "laced" rectum [3].
The main criteria for the diagnosis of decompensation of hemorrhoids

* Anorectal bleeding
* Characteristic pain syndrome
* Bulging hemorrhoidal
* Unnatural discharge from the rectum
* Swelling and abnormal sensation in the perianal area
* Dissatisfaction with the act of defecation

When SH is also possible discharge of mucus or pus in the stool. SH III and IV stages can be brand viagra complicated by thrombosis, ulceration and gangrene nevpravlyaemyh or affected by PG, which is accompanied by increased pain, signs of systemic toxicity and / or fever.

At the end of the often recurrent course in WG may be formed failure of internal sphincter and rectum and fecal incontinence.

Diagnosis

In a survey of the patient, in addition to the collection of active complaints, be sure to specify the nature of the bowel, the parameters of the chair, the mode of using laxatives.

The diagnosis of an acute attack of hemorrhoids, NY, or thrombosis of hemorrhoids is easy to put under examination the anus and rectum in the normal state, as well as straining the patient kolennoloktevom position and with good lighting. Perianal and rectal finger study rectovaginal study in complicated hemorrhoids may be accompanied by severe pain and therefore in need of a terminal surface anesthesia.

Detailed diagnosis of WG, as well as a differential diagnosis with other diseases of anorectal band performed at anoscopy or sigmoidoscopy to the level of 15-60 cm above the anus. For the formation of the diagnosis and choice of adequate treatment strategy is viagra the search for drugs important to remember anatomofiziologicheskih differences between external and internal hemorrhoids cause different pain sensitivity and risk of systemic complications in these two forms of the disease [3]. In clinical practice, not uncommon, and concomitant localization of the hemorrhoids.

Treatment

The choice of tactics and methods of hemorrhoid treatment in each case based on: assessment of severity of patient's general condition, severity of pain and degree of disability the patient, location and severity of hemorrhoids, the presence of complications, such as impairing or thrombosis of hemorrhoids; plans for a patient to treat the disease in future. Figure 1 reflects all the currently known methods of hemorrhoid treatment.

Conservative therapy

Drug therapy is widely used for a course of planned and preventive treatment of hemorrhoids, as well as in preparation for radical surgery or noninvasive surgical treatment, and as part of combination therapy in the postoperative period. Decompensation hemorrhoids conservative pharmacological treatment, in most cases local, is a means of providing emergency assistance to the patient [1].

Main part of conservative therapy - the use of topical agent for the rapid and effective analgesia anorectal zone. To this end, traditionally used surface mestnoanesteziruyuschih drugs: benzocaine, dicaine and others that may be used by applications, but more often in combined ointments, creams and suppositories. Traditionally in officinal formulations for the treatment of hemorrhoids combined with anesthetics mestnodeystvuyuschimi anti-inflammatory and astringent agents or glucocorticoids. As part of the complex before or postoperative therapy, as well as in complicated forms of hemorrhoids for analgesia and anti-inflammatory to increasingly use non-steroidal anti-inflammatory drugs.

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Chủ Nhật, 2 tháng 1, 2011

Statement

Last week South Korean scientists reported successful therapeutic cloning of human beings. They allegedly failed to grow three dozen embryos until the moment when they consisted of about a hundred cells, and from one embryo to obtain material for further research.

In the experiment, was obtained 30 cloned embryos, but only one of them managed to get stem cells. Further experiments with them have shown that the resulting line of embryonic stem cells can give rise to various tissues and organs. It is in this perspective of their use in medicine - you can grow organs for humans from his own cells.

Recall that the individual stages of the experiment, described in the latest brand name viagra issue of the journal Science, were made earlier. For example, in 2001 a team of American experts from the company Advanced Cell Technology has received a human embryo, but also destroyed it at an early stage of development. Constantly conducted experiments on stem cells from an adult organism.

What is actually an experiment consisted of South Korean scientists? How realistic it seems today, human cloning? His opinion on the "loud" statement on cloning human embryos express Elena Zakharova, embryologist Medical Clinics reproduction "MA-MA and Senior Researcher, Laboratory of Genetics of IOGen Sciences, Ph.D., embryologist Medical Clinics reproduction" MA-MA "Dmitry A. Isayev.

Cloned human embryo - an embryo produced not by the merger of sperm with an egg, and as a result of transplantation of the egg, previously devoid of its own genetic material, the nuclei of somatic human cells. Such an embryo genetically identical to the person from whom the somatic cell was taken. If the cloned embryo is transferred into the woman's uterus, it is theoretically possible (proof of this yet) to get the pregnancy and the birth of a human clone.

Another, more practical and promising option of using cloning technology to obtain embryonic stem cell lines from cloned human embryo (blastocyst) with the aim of therapeutic cloning. Embryonic stem cells can give rise to all cell types shown in our body. Perhaps scientists will never be able to grow these stem cells in the brain or heart, but of course, cell therapy will find its place in medicine of the future.

The aim of the present study was to obtain embryonic stem cell lines from cloned embryos, rather than the birth of a human clone. In this statement we are talking about therapeutic cloning.

To obtain cloned embryos have been used 176 oocytes. In each oocyte, after removal of their own genetic material was transplanted somatic follicular cells (the cells surrounding the oocyte during its maturation in the ovaries). Thus, all cloned embryos had a female genotype and had a genetic copy of the woman, the follicular cells which have been used. Only 25% of cloned embryos could develop to the blastocyst stage, and only 20 of them were able to use for stem-cell lines. As a result, large-scale experiment was obtained and studied only one (!) Line of embryonic stem cells genetically identical to the donor organism.

Although it is too early to talk about the widespread use of cloning technology (as long as it is only the first positive result), presented work is elegant and beautifully performed fundamental research, the results of which will undoubtedly contribute to the understanding of complex biological processes.

In the latest issue of the online version of the famous journal Science published an article by South Korean scientist Woo Suk Hwang and colleagues about how to obtain embryonic stem cells (ESCs) from the "cloned" human embryo (Hwang et al., Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst / / Science. 2004 Feb 12).

Depending on the goal-setting to distinguish between therapeutic and reproductive cloning. The purpose of reproductive cloning is the creation of "new" body-clone - a genetic copy of the living, or even long-dead creatures, in this case - the person. Therapeutic cloning aims to create an external supply of human ESCs for possible future treatment of diseased or damaged organs through stem cell therapy. Reproductive cloning is of great scientific and practical importance for the livestock, but when it comes to human cloning - unanimously condemned by the public and the overwhelming majority of scientists. Therapeutic cloning is accepted by scientists and physicians, but with a very significant reservations, as can be achieved in different ways:

1) transplanting the nuclei of cells in the adult donor eggs and the release of ESCs from embryos obtained in this manner;
2) allocation of ESCs from abortive material;
3) separation from the body's cells, such as bone marrow, and "treatment" of a state of ESCs;
4) separation of cells from the developing embryo.

Two recent fashion do not cause moral objections, but at least for now, technically unfeasible.

In the article scientists from Seoul National University, we are talking about therapeutic cloning. Prior to its publication, this sensational writing team for a long time conducted similar brand name drugs experiments with embryos of cattle and pigs. Then carried out experiments similar to those by P. Zavos.

For obtaining human ESCs Dr. Hwang and his colleagues used the "classic" approach: donor eggs from a remote pre-core nucleus of body cells transplanted adult human embryos cultured to the blastocyst stage and then extracted stem cells from them. This attracted the attention of the media - exactly the same way by reproductive cloning! No need to rush to condemn Korean scientists - they themselves are a very responsible attitude to the results of their experiments, in addition to South Korea cloning is prohibited.

Efficiency of obtaining ESCs from cloned blastocysts rights in the work of Korean scientists is low, so that to the practical application of the results of such experiments in regenerative medicine is still very far - despite the clearly designated target at the moment they have only academic value. At the same time, some three dozen cloned blastocysts - this is a sufficiently large number, making you more seriously the claims of the birth of cloned children.

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